Decreased Serum AHA Levels in Rheumatic Diseases
Author Information
Author(s): P. Vergne, V. Praloran, R. Treves, Y. Denizot
Primary Institution: CHRU Dupuytren and Laboratoire d'Hématologie Expérimentale, Limoges, France
Hypothesis
Serum PAF acetylhydrolase activity levels are decreased in patients with rheumatoid arthritis or osteoarthritis compared to healthy controls.
Conclusion
Patients with rheumatoid arthritis and osteoarthritis have significantly lower serum AHA levels compared to healthy individuals.
Supporting Evidence
- Serum AHA levels were significantly decreased in patients with rheumatoid arthritis and osteoarthritis compared to healthy controls.
- AHA levels in synovial fluid were not significantly different between rheumatoid arthritis and osteoarthritis patients.
- Serum and synovial fluid AHA levels were correlated in patients with rheumatoid arthritis and osteoarthritis.
Takeaway
People with certain joint diseases have less of a substance in their blood that helps control inflammation, which might explain why they have more inflammation.
Methodology
AHA levels were measured in serum and synovial fluid from patients with rheumatoid arthritis and osteoarthritis, and compared to healthy controls.
Participant Demographics
54 patients with rheumatoid arthritis (average age 61.2 years), 26 patients with osteoarthritis (average age 67.7 years), and 74 healthy controls (average age 50.7 years).
Statistical Information
P-Value
0.0004
Statistical Significance
p<0.0004
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