Antibiotics to Prevent Preterm Delivery in Twins
Author Information
Author(s): Mark T. Peters, Charles E.L. Brown, Audrey Baum, Rick Risser
Primary Institution: University of Texas Southwestern Medical Center at Dallas
Hypothesis
Does prophylactic treatment with oral broad-spectrum antimicrobial therapy improve pregnancy outcomes in twin gestations?
Conclusion
Prophylactic oral broad-spectrum antimicrobial therapy did not improve gestational age at delivery, birth weight, or neonatal complications in twin pregnancies.
Supporting Evidence
- The mean gestational ages at delivery were similar in both groups (35.9 weeks vs. 35.7 weeks).
- There was no significant difference in birth weight between the drug and placebo groups (2,358 g vs. 2,344 g).
- The incidence of respiratory distress syndrome was similar in both groups (8/142 vs. 5/140).
- Adverse effects were reported by 30 patients, including nausea and vomiting.
- Overall compliance was similar between the drug and placebo groups.
Takeaway
The study tested if giving antibiotics to pregnant women with twins could help them have healthier babies, but it didn't make a difference.
Methodology
Patients with twin gestations between 24 and 32 weeks were randomized to receive amoxicillin/clavulanic acid or placebo.
Potential Biases
The population studied was economically disadvantaged, which may not represent the general population.
Limitations
The study did not test for specific microorganisms that might cause preterm labor, which could affect the results.
Participant Demographics
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