Heart and Kidney Damage in Hypertensive Diabetic Patients
Author Information
Author(s): Cea-Calvo Luis, Conthe Pedro, Gómez-Fernández Pablo, de Alvaro Fernando, Fernández-Pérez Cristina
Primary Institution: Merck Sharp & Dohme, Madrid, Spain
Hypothesis
What is the prevalence of cardiac and renal damage in patients with hypertension and type 2 diabetes, and how does it relate to established cardiovascular disease?
Conclusion
Cardiac and renal damage are common in patients with hypertension and type 2 diabetes, and their presence is associated with a higher prevalence of established cardiovascular disease.
Supporting Evidence
- 22.9% of patients had left ventricular hypertrophy.
- 45.1% had a glomerular filtration rate of less than 60 ml/min/1.73 m2.
- 58.7% showed abnormal urinary albumin excretion.
Takeaway
Doctors found that many patients with high blood pressure and diabetes have heart and kidney problems, which can lead to more serious heart issues.
Methodology
This was a multicentre, cross-sectional study involving 293 investigators who collected data from patients aged 55 and older with hypertension and type 2 diabetes.
Potential Biases
Selection bias may have occurred as patients were included consecutively, potentially favoring those with more severe conditions.
Limitations
The study's cross-sectional design limits the ability to establish cause-effect relationships, and the sample may not represent the general population of hypertensive diabetic patients.
Participant Demographics
Mean age was 68.9 years, with 48.2% females and 51.3% having established cardiovascular disease.
Statistical Information
P-Value
p<0.001
Confidence Interval
[95%CI 1.43–3.38]
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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