Supersaturated Gel Formulation of Atorvastatin for Better Solubility and Stability
Author Information
Author(s): Park Jin Woo, Lee Sa-Won, Lee Jun Hak, Park Sung Mo, Cho Sung Jun, Maeng Han-Joo, Cho Kwan Hyung
Primary Institution: Inje University
Hypothesis
Can a supersaturated gel formulation improve the solubility, dissolution, and physical stability of atorvastatin?
Conclusion
The developed supersaturated gel formulation significantly enhances atorvastatin's solubility and dissolution rates compared to the commercial product.
Supporting Evidence
- The gel formulation showed over 95% dissolution rate within 2 hours at pH 1.2.
- The optimized formulation maintained physical stability without recrystallization for 100 days.
- The solubility of atorvastatin was significantly improved in the gel compared to its original form.
Takeaway
Researchers created a special gel to help a medicine called atorvastatin dissolve better in the stomach, making it work more effectively.
Methodology
The study involved developing a gel formulation using PEG 200 and TPGS, testing solubility and dissolution rates in various pH conditions.
Limitations
The study may not account for all potential interactions in the gastrointestinal tract.
Digital Object Identifier (DOI)
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