Differences Between Early-Onset and Adult-Onset Multiple Sclerosis in Iran
Author Information
Author(s): Ashtari Fereshteh, Shaygannejad Vahid, Farajzadegan Ziba, Amin Ali
Primary Institution: Isfahan University of Medical Sciences
Hypothesis
This study sought to identify the characteristics of early-onset Multiple Sclerosis (EOMS) compared to adult-onset form (AOMS) in Isfahan, Iran.
Conclusion
Early-onset MS does not significantly differ from adult form in terms of major clinical manifestation and course of disease, but seizures are more common in EOMS.
Supporting Evidence
- The mean age at onset was 14 ± 1.9 years for EOMS and 27.7 ± 8.06 years for AOMS.
- Seizures occurred more frequently in EOMS than in AOMS (12.6% vs. 1.6%).
- Optic neuritis was the most common presenting symptom in EOMS, while paresthesia was most common in AOMS.
Takeaway
This study looked at kids and adults with multiple sclerosis to see how their symptoms and disease progress differ. It found that kids have more seizures, but otherwise, their MS is pretty similar to adults'.
Methodology
This prospective study compared 104 youths with early-onset MS and 123 adults with adult-onset MS over a mean period of 5 years.
Limitations
Some patients were excluded from the study due to ceased follow-up.
Participant Demographics
The study included 104 patients with early-onset MS and 123 patients with adult-onset MS, with a female/male ratio of 4.47:1 in EOMS and 3.92:1 in AOMS.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
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