L-lysine as a treatment for schizophrenia
Author Information
Author(s): Wass Caroline, Klamer Daniel, Katsarogiannis Evangelos, Pålsson Erik, Svensson Lennart, Fejgin Kim, Bogren Inga-Britt, Engel Jörgen A, Rembeck Birgitta
Primary Institution: The Sahlgrenska Academy at University of Gothenburg
Hypothesis
Can L-lysine, an amino acid that interferes with nitric oxide production, improve symptoms in patients with schizophrenia?
Conclusion
L-lysine treatment significantly increased blood levels of L-lysine and reduced positive symptoms of schizophrenia, but further evaluation is needed.
Supporting Evidence
- L-lysine treatment increased blood concentration of L-lysine significantly.
- Patients showed a significant decrease in positive symptoms as measured by PANSS.
- Three patients reported subjective improvements in symptoms and cognitive functioning.
Takeaway
This study tested if L-lysine could help people with schizophrenia feel better. It seemed to help some patients feel less sick.
Methodology
10 patients with schizophrenia received 6 g/day of L-lysine or placebo in a cross-over design for 8 weeks.
Potential Biases
Potential placebo effects may have influenced the results.
Limitations
The small sample size limits the ability to draw strong conclusions about L-lysine's efficacy.
Participant Demographics
Patients were diagnosed with schizophrenia and on stable doses of antipsychotic medication.
Statistical Information
P-Value
0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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