Time and frequency domain analysis of heart rate variability in cattle affected by bovine spongiform encephalopathy
2011

Heart Rate Variability in Cattle with BSE

Sample size: 450 publication Evidence: moderate

Author Information

Author(s): Timm Konold, Gemma E Bone, Marion M Simmons

Primary Institution: Animal Health and Veterinary Laboratories Agency

Hypothesis

BSE in cattle causes changes in the autonomic nervous system.

Conclusion

HRV analysis was not useful to distinguish BSE-positive from BSE-negative cattle grouped by gender.

Supporting Evidence

  • Statistically significant differences were found for low or high frequency power based on gender.
  • HRV indices appeared to be mainly influenced by gender.
  • Abnormalities in the electrocardiogram were detected in 3% of the recordings.

Takeaway

The study looked at how the heart rate of cattle changes when they have a disease called BSE, but it found that the heart rate changes didn't help tell if a cow had the disease.

Methodology

The study analyzed heart rate variability from 1048 ECG recordings of cattle, comparing those with BSE to controls.

Potential Biases

Potential bias due to the varied methods of inoculation and the subjective nature of behavior scoring.

Limitations

The study included cattle inoculated by different routes and with different strains, which may affect the results.

Participant Demographics

The study involved 450 adult cattle, primarily Holstein-Friesians, with a mix of genders and BSE statuses.

Statistical Information

P-Value

< 0.0001

Statistical Significance

p<0.05

Digital Object Identifier (DOI)

10.1186/1756-0500-4-259

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