Expansion of Regulatory T Cells in Patients with Langerhans Cell Histiocytosis
Author Information
Author(s): Senechal Brigitte, Elain Gaelle, Jeziorski Eric, Grondin Virginie, Patey-Mariaud de Serre Natacha, Jaubert Francis, Beldjord Kheira, Lellouch Arielle, Glorion Christophe, Zerah Michel, Mary Pierre, Barkaoui Mohammed, Emile Jean Francois, Boccon-Gibod Liliane, Josset Patrice, Debré Marianne, Fischer Alain, Donadieu Jean, Geissmann Frederic
Primary Institution: INSERM, U838, Laboratory of Biology of the Mononuclear Phagocyte System, Necker Enfants Malades Institute, Paris, France
Hypothesis
The study investigates the nature of proliferating cells and the immune mechanisms involved in LCH granulomas.
Conclusion
Langerhans cell accumulation in LCH results from survival rather than uncontrolled proliferation, and is associated with the expansion of regulatory T cells.
Supporting Evidence
- The majority of proliferating cells in LCH lesions were found to be endothelial cells, fibroblasts, and polyclonal T lymphocytes.
- FoxP3+ T-regs were expanded in the blood of LCH patients with active disease.
- Patients with LCH exhibited an impaired skin delayed-type hypersensitivity response.
Takeaway
This study found that in children with a rare disease called LCH, certain immune cells called regulatory T cells grow more than usual, which might help the disease persist.
Methodology
The study analyzed biopsies and blood samples from 40 pediatric patients to identify proliferating cells in LCH granulomas.
Limitations
The study was based on a small number of patients due to the rarity of the disease.
Participant Demographics
Patients aged 0.25 to 13 years, mean age 7.8 years.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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