Faecal Microbiota Transplant for Diarrhoea in Critically Ill Patients
Author Information
Author(s): Cibulkova Ivana, Rehorova Veronika, Soukupova Hana, Waldauf Petr, Cahova Monika, Manak Jan, Matejovic Martin, Duska Frantisek
Primary Institution: Kralovske Vinohrady University Hospital, Prague, Czech Republic
Hypothesis
We hypothesise that FBT will be feasible as first-line treatment of postantibiotic diarrhoea in the critically ill, including those with uncomplicated CDI.
Conclusion
The study aims to evaluate the effectiveness of faecal microbiota transplantation in treating antibiotic-associated diarrhoea in critically ill patients.
Supporting Evidence
- Faecal microbiota transplantation has been effective for dysbiosis in non-critically ill patients.
- Animal experiments suggest FMT may reduce colonization with multi-drug resistant bacteria.
- Current standard treatments for antibiotic-associated diarrhoea lack robust evidence.
Takeaway
This study is testing if giving healthy stool to sick patients can help them stop having diarrhea caused by antibiotics.
Methodology
This is a prospective, multi-centre, randomized controlled trial with a 1:1 ratio of intervention to control groups.
Potential Biases
There is a risk of bias due to the unblinded nature of the study.
Limitations
The study may not account for all potential complications of FMT in critically ill patients.
Participant Demographics
Critically ill patients aged over 18 years with antibiotic-associated diarrhoea.
Digital Object Identifier (DOI)
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