Monitoring Salicylic Acid and Acetylsalicylic Acid in Pharmaceuticals
Author Information
Author(s): j. M. L6pez Fernindez, M. D. Luque de Castro, M. Valcircel
Primary Institution: University of Córdoba
Hypothesis
Can a new FIA manifold effectively determine salicylic acid and acetylsalicylic acid simultaneously in pharmaceutical preparations?
Conclusion
The study demonstrates that the FIA method can successfully monitor the dissolution of aspirin tablets by determining both salicylic acid and acetylsalicylic acid.
Supporting Evidence
- The FIA method allows for high automation in monitoring pharmaceutical dissolution tests.
- Two FIA peaks were observed corresponding to salicylic acid and the overall content.
- The method was optimized for various chemical and FIA variables.
- Calibration graphs for salicylic acid and acetylsalicylic acid were linear over specified concentration ranges.
Takeaway
This study shows a new way to check how well aspirin dissolves in water by measuring two important acids at the same time.
Methodology
An asymmetrical FIA merging-zones manifold was developed for simultaneous determination of salicylic acid and acetylsalicylic acid using photometric monitoring.
Limitations
The method may not directly sense the active component of the pharmaceutical.
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