CETP Gene Variants and Left Main Coronary Artery Disease
Author Information
Author(s): Kolovou Genovefa, Vasiliadis Ioannis, Kolovou Vana, Karakosta Agathi, Mavrogeni Sophie, Papadopoulou Evaggelia, Papamentzelopoulos Spiridon, Giannakopoulou Vasiliki, Marvaki Apostolia, Degiannis Dimitrios, Bilianou Helen
Primary Institution: Onassis Cardiac Surgery Center
Hypothesis
Can common variants of the cholesteryl ester transfer protein gene help identify individuals at risk for left main coronary artery disease?
Conclusion
The TaqIB polymorphism may be important for screening high-risk individuals for coronary artery disease, but it cannot differentiate between left main and more peripheral coronary artery disease.
Supporting Evidence
- Patients with LMCAD had a higher frequency of the B1B1 genotype compared to controls.
- The frequency of the B2B2 genotype was significantly lower in the LMCAD group.
- The B1 allele was more frequent in the LMCAD group compared to controls.
Takeaway
This study looked at how certain genes might affect heart disease. It found that one gene variant could help spot people at risk for serious heart problems.
Methodology
DNA analysis of 471 subjects for TaqIB and I405V polymorphisms in the CETP gene.
Potential Biases
Potential bias due to the study being conducted in a single geographic area with specific demographic characteristics.
Limitations
The sample size is small and the study is limited to a specific population, which may not be generalizable.
Participant Demographics
471 subjects of Greek origin, including 133 with left main coronary artery disease, 241 with more peripheral coronary artery disease, and 97 healthy controls.
Statistical Information
P-Value
0.001
Statistical Significance
p = 0.001
Digital Object Identifier (DOI)
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