Gr-1+CD11b+ Myeloid-Derived Suppressor Cells: Formidable Partners in Tumor Metastasis
2010
Myeloid-Derived Suppressor Cells and Tumor Metastasis
publication
Evidence: moderate
Author Information
Author(s): Yang Li, Claire M Edwards, Gregory R Mundy
Primary Institution: Vanderbilt University Medical Center
Hypothesis
Do Gr-1+CD11b+ myeloid-derived suppressor cells (MDSCs) contribute to tumor metastasis and osteolysis?
Conclusion
MDSCs play a significant role in tumor metastasis and may contribute to osteoclastogenesis in bone metastases.
Supporting Evidence
- MDSCs are overproduced in tumor-bearing hosts, including cancer patients.
- MDSCs can differentiate into osteoclasts, contributing to bone disease.
- TGF-β produced by MDSCs suppresses immune responses.
- MDSCs promote tumor angiogenesis and invasion.
- Blocking MDSC function may enhance cancer treatment efficacy.
Takeaway
Some special cells in the body help tumors grow and spread by stopping the immune system from fighting them, and they might also help break down bones.
Digital Object Identifier (DOI)
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