A Commander-independent function of COMMD3 in endosomal trafficking
2024
COMMD3's Role in Endosomal Recycling
publication
Author Information
Author(s): Squiers Galen T., Wan Chun, Gorder James, Puscher Harrison, Shen Jingshi
Primary Institution: Cold Spring Harbor Laboratory
Hypothesis
Does COMMD3 have a function in endosomal recycling independent of the Commander complex?
Conclusion
COMMD3 can regulate cargo proteins in endosomal recycling without the need for the Commander complex.
Supporting Evidence
- COMMD3 regulates cargo proteins independently of the Commander complex.
- The N-terminal domain of COMMD3 binds and stabilizes ARF1.
- Mutations that disrupt the COMMD3-ARF1 interaction impair cargo recycling.
Takeaway
COMMD3 helps move proteins inside cells even when it's not working with its usual team, the Commander complex.
Methodology
Genetic screens and targeted mutations were used to study the function of COMMD3.
Digital Object Identifier (DOI)
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