p53 Protein Expression in Human Breast Carcinoma
Author Information
Author(s): D.N. Poller, C.E. Hutchings, M. Galea, J.A. Bell, R.A. Nicholson, C.W. Elston, R.W. Blarney, I.O. Ellis
Primary Institution: City Hospital, Nottingham, UK
Hypothesis
What is the relationship between p53 protein expression and other prognostic factors in breast carcinoma?
Conclusion
p53 protein expression is common in human breast cancer and is associated with high tumor grade and negative estrogen receptor status.
Supporting Evidence
- 42.5% of invasive carcinomas showed positive p53 immunoreactivity.
- High tumor grade was significantly associated with p53 expression.
- Negative estrogen receptor status was significantly associated with lack of p53 expression.
- p53 expression was rare in invasive lobular carcinoma.
Takeaway
This study looked at how a protein called p53 behaves in breast cancer. It found that when p53 is present, it often means the cancer is more aggressive.
Methodology
The study examined p53, EGFR, c-erbB-2, and estrogen receptor expression in 149 breast carcinoma cases using immunohistochemistry.
Limitations
The study may not have included enough cases of rare breast cancer types for meaningful analysis.
Participant Demographics
The study included 149 patients with primary symptomatic breast carcinomas.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
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