COCONUT 2.0: a comprehensive overhaul and curation of the collection of open natural products database
2025

COCONUT 2.0: A New Version of the Open Natural Products Database

publication Evidence: high

Author Information

Author(s): Chandrasekhar Venkata, Rajan Kohulan, Kanakam Sri Ram Sagar, Sharma Nisha, Weißenborn Viktor, Schaub Jonas, Steinbeck Christoph

Primary Institution: Friedrich Schiller University Jena

Conclusion

COCONUT 2.0 is a comprehensive and user-friendly resource that enhances the accessibility and curation of natural product data.

Supporting Evidence

  • COCONUT aggregates data from various sources, providing detailed information on hundreds of thousands of natural products.
  • The updated version includes a community curation feature that allows users to contribute to data accuracy.
  • COCONUT 2.0 has been designed to improve scalability, reliability, and usability for researchers.

Takeaway

COCONUT is like a big library for natural products where scientists can find and share information about different natural chemicals. The new version makes it easier for everyone to help keep the information accurate.

Methodology

The database was completely re-engineered, incorporating new data sources and a user-friendly curation interface.

Potential Biases

Potential for misclassification of synthetic compounds as natural products due to data aggregation.

Limitations

The database may still contain incorrect information from source databases and non-natural products.

Digital Object Identifier (DOI)

10.1093/nar/gkae1063

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