Estimating Chikungunya Prevalence in La Réunion Island Outbreak
Author Information
Author(s): Gérardin Patrick, Guernier Vanina, Perrau Joëlle, Fianu Adrian, Le Roux Karin, Grivard Philippe, Michault Alain, de Lamballerie Xavier, Flahault Antoine, Favier François
Primary Institution: Centre d'Investigation Clinique – Épidémiologie Clinique (CIC – EC) de La Réunion
Hypothesis
The study aims to refine clinical estimates of Chikungunya attack rates using serological assessments.
Conclusion
A rapid serosurvey in pregnant women can effectively assess attack rates during epidemics, while a population-based survey provides insights into herd immunity.
Supporting Evidence
- The rapid survey found an 18.2% seroprevalence rate among pregnant women.
- The population-based survey estimated a 38.2% seroprevalence in the community.
- The rapid survey provided a rough estimate of 143,000 infected cases during the epidemic.
- The population-based survey estimated about 300,000 infected cases post-epidemic.
Takeaway
The study looked at how many people got sick from Chikungunya on La Réunion Island by testing blood samples from pregnant women and the general community.
Methodology
Two serosurveys were conducted: one with pregnant women during the epidemic and another with a random community sample post-epidemic.
Potential Biases
Potential selection bias from non-representative sampling of pregnant women.
Limitations
The rapid survey may have selection bias due to non-random sampling of laboratories.
Participant Demographics
Pregnant women for the rapid survey and a random sample of the community for the population-based survey.
Statistical Information
P-Value
<0.001
Confidence Interval
95% CI, 35.9 to 40.6%
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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