Cleft Palate and Presurgical Orthopedics: A Systematic Review and Meta-Analysis
Author Information
Author(s): Rabal-Soláns Ana, Mediero-Pérez Carmen, Yáñez-Vico Rosa M.
Primary Institution: Complutense University of Madrid
Hypothesis
Did presurgical orthopedics in patients with CLP affect intra-arch dimensions before surgery?
Conclusion
This meta-analysis found no statistically significant effects of presurgical orthopedic treatment on maxillary arch dimensions in infants with cleft lip and palate during the first year of life.
Supporting Evidence
- The results showed similar alveolar cleft widths with clinical differences in favor of PSO.
- Comparable posterior cleft widths were found with and without PSO in CLP babies.
- Further high-quality randomized controlled trials are needed to definitively establish the efficacy of PSO.
Takeaway
The study looked at whether special treatments before surgery help babies with cleft lip and palate grow better. It found that these treatments didn't make a big difference in how their mouths grew.
Methodology
The review followed PRISMA guidelines and included a comprehensive electronic search across multiple databases, with two reviewers conducting study selection and data extraction.
Potential Biases
The estimated potential risk of bias was low for one study, moderate for two, and high for two studies, mainly related to selection bias.
Limitations
The main limitation is the lack of studies with large patient samples due to the low prevalence of cleft lip and palate.
Participant Demographics
The studies included a total sample of 365 neonates, of whom 145 had cleft lip and/or palate and received presurgical orthopedics.
Statistical Information
P-Value
p = 0.30
Confidence Interval
95% CI, −8.03 to 2.70
Digital Object Identifier (DOI)
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