Blood Cell Changes in Lung Cancer Patients After Surgery
Author Information
Author(s): Alessandro Bonis, Francesca Lunardi, Giulia Pagliarini, Vincenzo Verzeletti, Luigi Lione, Alberto Busetto, Giorgio Cannone, Giovanni Maria Comacchio, Marco Mammana, Eleonora Faccioli, Alessandro Rebusso, Marco Schiavon, Samuele Nicotra, Andrea Dell’Amore, Federico Rea, Tawee Tanvetyanon
Primary Institution: University of Padova, Italy
Hypothesis
Do peripheral blood cell counts differ based on the immune status of lung adenocarcinoma patients?
Conclusion
Lung adenocarcinoma patients with an active tumor inflammatory microenvironment show distinct blood cell profiles compared to those with a silent immune profile.
Supporting Evidence
- TIME-active patients had a higher preoperative lymphocyte count.
- TIME-active patients had a lower neutrophil rate before surgery.
- Post-surgery, blood cell counts normalized between groups.
- Overall survival was significantly better in TIME-active patients.
- Neutrophil-to-lymphocyte ratio was significantly different preoperatively.
Takeaway
This study found that patients with active immune responses to lung cancer have different blood cell counts than those without such responses, especially before and after surgery.
Methodology
This is a retrospective study analyzing blood cell counts in lung adenocarcinoma patients before and after surgery, comparing those with active and silent immune profiles.
Potential Biases
Potential selection bias due to the small, highly selected sample.
Limitations
The study has a small sample size and does not assess the specific types of circulating lymphocytes.
Participant Demographics
Median age of 71 years, with 59% female and 54% active smokers.
Statistical Information
P-Value
p = 0.02 for lymphocyte count, p = 0.01 for neutrophil rate, p = 0.02 for overall survival.
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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