Analysis of SARS-CoV-2 Variants in Guinea
Author Information
Author(s): Mbaye Aminata, Diallo Haby, Gnimadi Thibaut Armel Cherif, Kadio Kadio Jean Jacques Olivier, Soumah Abdoul Karim, Koivogui Joel Balle, Monemou Jean Louis, Povogui Moriba Kowa, Kaba Djiba, Hounmenou Castro, Serrano Laetitia, Butel Christelle, Nuñez Nicolas Fernandez, Vidal Nicole, Guichet Emilande, Delaporte Eric, Ayouba Ahidjo, Peeters Martine, Toure Abdoulaye, Keita Alpha Kabinet
Primary Institution: Centre de Recherche et de Formation en Infectiologie de Guinée (CERFIG), Université Gamal Abder Nasser de Conakry, Conakry, Guinea
Hypothesis
This study aimed to determine the SARS-CoV-2 lineages and better characterize the dynamics of the pandemic during the different waves in Guinea.
Conclusion
The study provides insights into the epidemic dynamics of SARS-CoV-2 in Guinea, highlighting the significant variants that circulated and the importation and exportation of the virus during the pandemic.
Supporting Evidence
- The study analyzed 363 samples of SARS-CoV-2 variants collected in Guinea.
- Results showed the circulation of SARS-CoV-2 in three distinct periods with different lineages.
- Significant variants included Alpha, Delta, and Omicron, with the majority being Omicron during the later period.
- Importation and exportation of the virus were noted between Guinea and neighboring countries.
Takeaway
The researchers looked at different versions of the COVID-19 virus in Guinea to see how they spread over time and found that some versions were brought in from other countries.
Methodology
Whole genome sequencing of 363 samples with PCR cycle threshold (Ct) values under thirty was undertaken between May 2020 and May 2023 using Illumina iSeq 100 technology.
Limitations
Sub-sampling and degradation of samples for sequences were observed, and organization and collaboration between laboratories are needed for better sample collection and storage.
Participant Demographics
{"gender_distribution":{"male":64,"female":35,"unknown":1},"age_distribution":{"under_20":9.1,"20_to_40":51.9,"41_to_60":28.8,"over_60":10}}
Digital Object Identifier (DOI)
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