Chinese Herbal Preparation Reduces Adhesion Molecules Linked to Heart Disease
Author Information
Author(s): Kylie A. O'Brien, Ling Shanhong, Abbas Estelle, Dai Aozhi, Zhang Jiansheng, Wang Wen Cheng, Bensoussan Alan, Luo Ruizhi, Guo Zhi-Xin, Komesaroff Paul A.
Primary Institution: Monash University Department of Medicine
Hypothesis
Does the Chinese herbal preparation Dantonic Pill reduce circulating adhesion molecules in individuals with mild to moderate hypercholesterolemia?
Conclusion
The study found that the Dantonic Pill significantly reduced levels of certain adhesion molecules associated with cardiovascular disease.
Supporting Evidence
- The Dantonic Pill reduced ICAM-1 levels by 9% and E-selectin levels by 15%.
- No significant changes were observed in the placebo group.
- The herbal preparation was well tolerated with no significant adverse effects.
Takeaway
A special herbal pill can help lower some bad proteins in the blood that are linked to heart problems.
Methodology
A parallel double-blind randomized placebo-controlled study was conducted over 12 weeks with 40 participants.
Potential Biases
Potential confounding factors such as psychological stress were not directly measured.
Limitations
The study had a small sample size and focused on healthy individuals not taking conventional medications.
Participant Demographics
Participants were healthy individuals aged 18 years and over with mild to moderate hypercholesterolemia.
Statistical Information
P-Value
.03
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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