Variation in the E2-binding domain of HPV 16 is associated with high-grade squamous intraepithelial lesions of the cervix
2001
HPV 16 E2 Variation and Cervical Lesions
Sample size: 239
publication
Evidence: moderate
Author Information
Author(s): Giannoudis A, Duin M van, Snijders P J F, Herrington C S
Primary Institution: University of Liverpool
Hypothesis
HPV 16 E2 variation is important in the development of high-grade squamous neoplasia of the cervix.
Conclusion
Disruption of the E2 gene regions is more frequent in high-grade lesions, indicating a potential role in the progression to high-grade intraepithelial disease.
Supporting Evidence
- 22 of 178 low-grade SILs contained HPV 16.
- 43 of 61 high-grade SILs examined contained HPV 16.
- No relationship was found between the E6 350T-G variant and lesion grade.
- Disruption of the E2 gene regions was significantly more frequent in high-grade lesions.
- There was a significant association between the 3684C-A variant in the E2 DNA binding domain and high-grade histology.
Takeaway
Scientists studied a virus linked to cervical cancer and found that certain changes in its genes are more common in serious cases.
Methodology
A cross-sectional analysis of low-grade and high-grade squamous intraepithelial lesions for specific mutations in the HPV 16 E2 gene.
Statistical Information
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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