Mucin-type Glycoprotein A-80 and Breast Cancer Prognosis
Author Information
Author(s): E.T. Eriksson, H. Schimmelpenning, L.-E. Rutqvist, H. Johansson, G.U. Auer
Primary Institution: Karolinska Institute and Hospital
Hypothesis
The expression of the mucin-type glycoprotein A-80 is related to the prognosis in breast cancer patients.
Conclusion
The study found that A-80 expression is associated with clinical outcomes in breast cancer patients.
Supporting Evidence
- 150 out of 173 tumors (87%) showed A-80 immunoreactivity.
- Patients with non-A-80 immunoreactive tumors had longer distant metastases-free survival times.
- The degree of A-80 expression was found to be of significant prognostic value in univariate analysis.
Takeaway
This study looked at a protein called A-80 in breast cancer and found that how much of it is present can help predict how well patients will do.
Methodology
Immunohistochemical staining was performed on surgical specimens from breast cancer patients, and the results were correlated with clinical follow-up data.
Limitations
The prognostic significance of A-80 expression was reduced in multivariate analysis, indicating that other factors also play a significant role.
Participant Demographics
Mean age of participants was 56 years, with a range from 34 to 70 years.
Statistical Information
P-Value
0.03
Statistical Significance
p<0.05
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