minet: A Package for Inferring Gene Networks
Author Information
Author(s): Meyer Patrick E, Lafitte Frédéric, Bontempi Gianluca
Primary Institution: Université Libre de Bruxelles
Hypothesis
The minet package can effectively infer large transcriptional networks from microarray data using mutual information.
Conclusion
The minet package provides a series of tools for inferring transcriptional networks from microarray data.
Supporting Evidence
- The minet package is freely available from the Comprehensive R Archive Network and Bioconductor.
- It implements four information-theoretic methods for network inference.
- The package includes tools for accuracy assessment like F-scores, PR-curves, and ROC-curves.
Takeaway
The minet package helps scientists understand how genes interact by analyzing data from experiments. It uses special math to find connections between genes.
Methodology
The package uses mutual information to infer networks from microarray datasets, implementing various algorithms and entropy estimators.
Limitations
The inferred networks may not represent proper biochemical regulatory networks and can miss physical connections between macromolecules.
Digital Object Identifier (DOI)
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