Enhanced expression of peroxisome proliferator-activated receptor gamma in epithelial ovarian carcinoma
2005
PPARγ Expression in Ovarian Cancer
Sample size: 56
publication
Evidence: moderate
Author Information
Author(s): G Y Zhang, N Ahmed, C Riley, K Oliva, G Barker, M A Quinn, G E Rice
Primary Institution: Royal Women's Hospital, Melbourne, Australia
Hypothesis
This study evaluates the expression of PPARγ in different pathological grades and subtypes of human epithelial ovarian tumours.
Conclusion
The study found that PPARγ expression is significantly higher in malignant ovarian tumours compared to benign and normal ovaries.
Supporting Evidence
- PPARγ was not expressed in normal ovaries.
- 26 out of 28 carcinomas studied were positive for PPARγ expression.
- An altered staining pattern of PPARγ was observed in high-grade ovarian tumours.
Takeaway
The study shows that a protein called PPARγ is found more in cancerous ovarian tissues than in normal ones, which might help us understand ovarian cancer better.
Methodology
The study used immunohistochemistry and Western blot analyses to evaluate PPARγ expression in ovarian tumour tissues.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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