Ethanol and Gastric Cancer in Rats
Author Information
Author(s): H. Iishil, M. Tatsutal, M. Babal, H. Taniguchi
Primary Institution: Centrefor Adult Diseases, Osaka
Hypothesis
Does ethanol promote gastric carcinogenesis in Wistar rats treated with MNNG?
Conclusion
Ethanol significantly increases the incidence and number of gastric cancers in rats treated with MNNG.
Supporting Evidence
- Ethanol increased the incidence of gastric cancers from 18% to 72%.
- All tumors were histologically highly well differentiated.
- Ethanol did not affect the histological types of gastric cancers.
- Ethanol significantly increased the labelling index of antral epithelial cells.
Takeaway
This study found that giving rats alcohol after a cancer-causing treatment made them more likely to develop stomach cancer.
Methodology
Wistar rats were treated with MNNG for 20 weeks and then given either ethanol or saline injections every other day for 32 weeks.
Limitations
The study only used male Wistar rats, which may limit the generalizability of the findings.
Participant Demographics
30 young male Wistar rats, 6 weeks old at the start of the study.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.05
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