Acute and cumulative effects of carboplatin on renal function
1990
Nephrotoxicity of Carboplatin
Sample size: 28
publication
Evidence: moderate
Author Information
Author(s): J.R. Hardy, S. Tan, I. Fryatt, E. Wiltshaw
Primary Institution: Royal Marsden Hospital
Hypothesis
Does high-dose carboplatin significantly affect renal function?
Conclusion
High-dose carboplatin causes a transient decline in renal function, but most patients recover afterwards.
Supporting Evidence
- Patients experienced a 19% reduction in glomerular filtration rate after treatment.
- Most patients showed recovery in renal function after treatment.
- Sequential GFR estimates at lower doses of carboplatin showed no significant decline.
Takeaway
Carboplatin can hurt your kidneys a little, but most people get better after treatment.
Methodology
Patients received high-dose carboplatin and had their glomerular filtration rate measured before, during, and after treatment.
Limitations
The study only included patients with no prior chemotherapy and may not represent all ovarian cancer patients.
Participant Demographics
Patients aged 33-66 years, median age 55, with stage III and IV ovarian cancer.
Statistical Information
P-Value
<0.0001
Statistical Significance
p<0.0001
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