Study of XRCC1 Gene and Stroke Response
Author Information
Author(s): Dutra Ana VC, Lin Hsiu-Fen, Juo Suh-Hang H, Mohrenweiser Harvey, Sen Souvik, Grewal Raji P
Primary Institution: New Jersey Neuroscience Institute
Hypothesis
Polymorphisms in genes encoding proteins involved in the cerebral response to ischemia could act as modifiers of this response and impact stroke volume.
Conclusion
The study suggests that the 'T' allele of the C26304T polymorphism is associated with larger stroke volumes in non-lacunar ischemic strokes.
Supporting Evidence
- The 'T' allele of the C26304T polymorphism is significantly associated with larger stroke volumes.
- Neither of the studied polymorphisms represented a risk factor for the development of stroke.
- The study included a case control association study with 113 control patients.
Takeaway
This study looks at how certain genes might affect how big a stroke is. They found that one gene variant is linked to larger strokes.
Methodology
The study involved 134 patients with non-lacunar ischemic strokes and 113 control patients, analyzing two polymorphisms in the XRCC1 gene.
Limitations
The study is limited by a relatively small sample size.
Participant Demographics
{"mean_age":70.8,"gender_distribution":{"female":73,"male":61},"ethnicity":{"Caucasian":93,"African_American":12,"Others":29}}
Statistical Information
P-Value
p < 0.008
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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