Risperidone for Conduct Disorder in Preschoolers
Author Information
Author(s): Ercan Eyup S, Basay Burge Kabukcu, Basay Omer, Durak Sibel, Ozbaran Burcu
Primary Institution: Ege University School of Medicine
Hypothesis
The study aims to evaluate the efficacy and tolerability of risperidone in preschool children with conduct disorder.
Conclusion
Risperidone may be an effective and well-tolerated treatment for conduct disorder in preschool children.
Supporting Evidence
- All patients were classified as 'responders' based on improvement scales.
- Risperidone was associated with a 78% reduction in the CGI Severity score.
- Significant improvements were detected on all subscales of the T-DSM-IV-S.
- Tolerability was good, with no serious adverse effects observed.
Takeaway
This study looked at how a medicine called risperidone can help young kids who have really bad behavior. It found that the medicine worked well and didn't cause serious problems.
Methodology
The study was an 8-week, open-label trial involving 12 preschoolers diagnosed with conduct disorder, with assessments conducted at 2-week intervals.
Potential Biases
The study design was open-label, which may introduce bias in reporting outcomes.
Limitations
The small sample size limits the statistical power, and the study duration was short, making long-term effects unknown.
Participant Demographics
The participants included 10 boys and 2 girls, aged around 42.4 months, from low to middle socioeconomic backgrounds.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website