Effects of Olanzapine on Metabolism in Healthy Volunteers
Author Information
Author(s): Vance L. Albaugh, Ravi Singareddy, David Mauger, Christopher J. Lynch
Primary Institution: The Pennsylvania State University College of Medicine
Hypothesis
Does olanzapine have acute metabolic effects in healthy volunteers similar to those observed in animal models?
Conclusion
Olanzapine administration in healthy volunteers leads to increased glucose levels and triglycerides, while decreasing free fatty acids and HDL cholesterol.
Supporting Evidence
- Olanzapine increased glucose Area Under the Curve (AUC) by 42%.
- Fasting plasma leptin increased by 24% after olanzapine treatment.
- Triglycerides increased by 22% after olanzapine treatment.
- Free fatty acids decreased by 32% after olanzapine treatment.
- High-density lipoprotein cholesterol decreased by 10% after olanzapine treatment.
Takeaway
This study shows that taking olanzapine can change how your body processes sugar and fat, which might lead to weight gain and diabetes.
Methodology
A double blind, randomized, placebo-controlled crossover trial with healthy volunteers receiving olanzapine or placebo for three days.
Potential Biases
Potential bias due to the small, homogeneous sample of healthy volunteers may not represent the general population.
Limitations
The study was limited by a small sample size and the short duration of olanzapine exposure.
Participant Demographics
15 healthy volunteers (8 males, 7 females), aged 18-30, with BMI 18.5-25.
Statistical Information
P-Value
0.0105
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website