Second Primary Malignancies After Treatment for Malignant Lymphoma
Author Information
Author(s): Okines A, Thomson C S, Radstone C R, Horsman J M, Hancock B W
Primary Institution: YCR Academic Unit of Clinical Oncology, Weston Park Hospital, Sheffield, UK
Hypothesis
To determine the incidence and possible causes of second primary malignancies after treatment for Hodgkin's and Non-Hodgkin's lymphoma.
Conclusion
Patients with high stage disease at diagnosis may have an increased risk of developing a second primary cancer.
Supporting Evidence
- 68 patients developed second cancers at least 6 months after their primary diagnosis.
- The crude incidence of second primary malignancies was 1.89% overall.
- 3.21% incidence among patients treated for Hodgkin's lymphoma.
- 1.32% incidence among patients treated for Non-Hodgkin's lymphoma.
- High stage at diagnosis was associated with a higher risk of developing a second primary cancer.
Takeaway
This study looked at patients who had lymphoma and found that some of them developed a second cancer after treatment, especially if they were diagnosed at a later stage.
Methodology
A cohort of 3764 patients diagnosed with HL or NHL was analyzed for subsequent primary malignancies using matched case-control design.
Potential Biases
Potential selection bias due to the exclusion of patients treated elsewhere.
Limitations
The study may have incomplete records and a relatively short follow-up duration.
Participant Demographics
Patients diagnosed with Hodgkin's and Non-Hodgkin's lymphoma between January 1970 and July 2001.
Statistical Information
P-Value
0.068
Confidence Interval
95% CI: 0.91–13.26
Statistical Significance
p=0.068
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website