Mutations in TP53 and CTNNB1 Related to Hepatitis B and C Infections in Liver Cancer Patients from Thailand
Author Information
Author(s): Galy Olivier, Chemin Isabelle, Le Roux Emilie, Villar Stéphanie, Le Calvez-Kelm Florence, Lereau Myriam, Gouas Doriane, Vieco Beatriz, Suarez Iris, Navas Maria-Cristina, Chevallier Michèle, Norder Helene, Srivatanakul Petcharin, Karalak Anant, Sangrajrang Suleeporn, Trépo Christian, Hainaut Pierre
Primary Institution: National Cancer Institute, Bangkok, Thailand
Hypothesis
The study investigates the relationship between HBV/HCV infections and TP53/CTNNB1 mutations in hepatocellular carcinoma (HCC) patients from Thailand.
Conclusion
The study found that TP53 and CTNNB1 mutations were not mutually exclusive, with a significant prevalence of HBV infections among the patients.
Supporting Evidence
- 73% of the cases had HBV DNA detected, including occult infections.
- 34.6% of patients had TP53 mutations, with a high proportion being the R249S mutation.
- CTNNB1 mutations were found in 23% of the cases.
Takeaway
This study looked at liver cancer patients in Thailand and found that many had mutations in important genes and were infected with hepatitis B virus.
Methodology
Patients were recruited from the National Cancer Institute in Bangkok, and their tumor and non-tumor tissues were analyzed for mutations and viral infections.
Limitations
The study is limited by its small sample size and the specific geographic focus, which may not represent broader populations.
Participant Demographics
The majority of patients were male (83.3%) with an age range from 17 to 73 years, and most cases occurred before 50 years of age.
Digital Object Identifier (DOI)
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