Mechanisms of gut homeostasis regulating Th17/Treg cell balance in PMOP
2024
Gut Homeostasis and Th17/Treg Cell Balance in Postmenopausal Osteoporosis
publication
Evidence: moderate
Author Information
Author(s): Qi Peng, Xie Ruixuan, Liu Hao, Zhang Zixuan, Cheng Yuan, Ma Jilong, Wan Kangwei, Xie XingWen
Primary Institution: Gansu University of Traditional Chinese Medicine
Hypothesis
How does gut homeostasis regulate the balance between Th17 and Treg cells in postmenopausal osteoporosis?
Conclusion
Targeting gut homeostasis to restore Th17/Treg balance may offer new treatment options for postmenopausal osteoporosis.
Supporting Evidence
- The gut microbiota significantly influences the balance between Th17 and Treg cells, which is crucial for bone health.
- Disruption of gut homeostasis can lead to increased bone resorption and decreased bone mass.
- Probiotics may help restore gut health and improve bone density in postmenopausal women.
Takeaway
This study shows that keeping the gut healthy can help balance certain immune cells that protect bones in women after menopause.
Digital Object Identifier (DOI)
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