Body Composition and Recurrence Risk in Triple-Negative Breast Cancer
Author Information
Author(s): Vis Jill B. De, Wang Cong, Nguyen Kirsten V., Sun Lili, Jia Brigitte, Sherry Alexander D., Alford-Holloway Mason N., Balbach Meredith L., Koyama Tatsuki, Chakravarthy A. Bapsi, Rafat Marjan
Hypothesis
VSR is a stronger predictor of recurrence compared with BMI in patients with TNBC.
Conclusion
VSR was associated with a significant risk of distant recurrence and may serve as a prognostic biomarker.
Supporting Evidence
- Triple-negative breast cancer patients are at increased risk for recurrence compared to other subtypes.
- VSR was significantly associated with an increased risk of distant recurrence.
- BMI was not associated with any recurrence risk.
Takeaway
Doctors looked at body fat measurements to see if they could predict if breast cancer would come back. They found that one specific measurement, VSR, was really good at predicting this.
Methodology
The study used CT imaging to measure body composition and assessed associations with recurrence risk using statistical models.
Participant Demographics
Women with stage I-III triple-negative breast cancer.
Statistical Information
P-Value
0.041
Confidence Interval
95% CI: 1.06–17.02
Statistical Significance
p=0.041
Digital Object Identifier (DOI)
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