GOLPH2 Expression in Renal Cell Cancer
Author Information
Author(s): Fritzsche Florian Rudolf, Riener Mark-Oliver, Dietel Manfred, Moch Holger, Jung Klaus, Kristiansen Glen
Primary Institution: Institute of Surgical Pathology, UniversitätsSpital Zürich
Hypothesis
What is the prognostic and diagnostic value of GOLPH2 in renal cell carcinoma?
Conclusion
GOLPH2 is expressed in normal renal tissue and is down-regulated in most clear cell renal cell carcinomas, with limited diagnostic or prognostic value in RCC.
Supporting Evidence
- GOLPH2 was highly expressed in normal renal tubules.
- Almost half of RCC cases showed GOLPH2 expression.
- GOLPH2 expression was significantly higher in papillary and chromophobe RCC compared to clear cell RCC.
- No significant associations with clinico-pathological parameters were found.
Takeaway
This study looked at a protein called GOLPH2 in kidney cancer and found it is present in normal kidney tissue but not very helpful for diagnosing or predicting outcomes in kidney cancer.
Methodology
GOLPH2 protein expression was analyzed by immunohistochemistry in 104 renal cell carcinoma cases compared to matched normal kidney tissue.
Limitations
The study cohort was medium-sized and primarily consisted of clear cell RCC, limiting the ability to detect prognostic value in other RCC subtypes.
Participant Demographics
81 men and 23 women, ages 28 to 92, median age 62.
Statistical Information
P-Value
0.057
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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