Palonosetron vs Ondansetron for Preventing Nausea After Surgery
Author Information
Author(s): Bajwa Sukhminderjit Singh, Kaur Sukhwinder, Sharma Jasbir, Singh Veenita, Singh Amarjit, Goraya SPS, Parmar SS, Singh Kamaljit
Primary Institution: Gian Sagar Medical College & Hospital, Ram Nagar, Banur, Punjab, India
Hypothesis
Is palonosetron more effective than ondansetron in preventing postoperative nausea and vomiting in day care surgery?
Conclusion
Palonosetron is more effective than ondansetron in preventing postoperative nausea and vomiting in patients undergoing day care surgery.
Supporting Evidence
- 20% of patients in the ondansetron group experienced nausea compared to 6.67% in the palonosetron group.
- 4 patients in the ondansetron group had vomiting episodes compared to 1 in the palonosetron group.
- The mean rescue dose of antiemetic was significantly higher in the ondansetron group (10.6 mg) compared to the palonosetron group (6.4 mg).
- Palonosetron has a longer duration of action than ondansetron.
Takeaway
This study found that palonosetron works better than ondansetron to stop people from feeling sick after surgery.
Methodology
A double-blind study comparing the effects of ondansetron and palonosetron on postoperative nausea and vomiting in 60 female patients undergoing laparoscopic gynecological surgery.
Potential Biases
Potential bias in patient selection and reporting of outcomes.
Limitations
The study only included female patients aged 25-40 and may not be generalizable to other populations.
Participant Demographics
60 ASA I/II female patients aged 25-40 years.
Statistical Information
P-Value
0.036
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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