Antimicrobial Resistance of Staphylococcus aureus in Madagascar
Author Information
Author(s): Randrianirina Frédérique, Soares Jean-Louis, Ratsima Elisoa, Carod Jean-François, Combe Patrice, Grosjean Pierre, Richard Vincent, Talarmin Antoine
Primary Institution: Institut Pasteur de Madagascar
Hypothesis
What is the current status of antibiotic resistance of Staphylococcus aureus in Antananarivo, Madagascar?
Conclusion
The rate of methicillin-resistant Staphylococcus aureus is not different between community-acquired and nosocomial infections and is still rather low in Madagascar.
Supporting Evidence
- The prevalence of MRSA was 6.5% for community-acquired strains and 4.4% for nosocomial infections.
- Resistance to tetracycline, trimethoprim-sulfamethoxazole, and erythromycin was more common.
- No isolates were resistant to glycopeptides.
- Eight MRSA isolates were multidrug resistant.
Takeaway
Doctors in Madagascar found that most Staphylococcus aureus germs are still treatable with antibiotics, which is good news for patients.
Methodology
Clinical S. aureus isolates were collected from patients, and susceptibility tests with 18 antibiotics were performed using the disk diffusion method.
Potential Biases
Potential overestimation of methicillin resistance due to testing conditions.
Limitations
Some strains may not have been responsible for infections, and the number of nosocomial strains was low.
Participant Demographics
367 females and 207 males, mean age 34.4 years old, range 1 month to 90 years old.
Statistical Information
P-Value
0.5
Confidence Interval
95%CI [32.9–35.9]
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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