Highly Pathogenic Avian Influenza Virus (H5N1) Isolated from Whooper Swans, Japan
2008

H5N1 Virus Found in Whooper Swans in Japan

Sample size: 4 publication Evidence: moderate

Author Information

Author(s): Uchida Yuko, Mase Masaji, Yoneda Kumiko, Kimura Atsumu, Obara Tsuyoshi, Kumagai Seikou, Saito Takehiko, Yamamoto Yu, Nakamura Kikuyasu, Tsukamoto Kenji, Yamaguchi Shigeo

Primary Institution: National Institute of Animal Health, Kannondai, Japan

Hypothesis

What is the genetic and pathogenic profile of the H5N1 virus isolated from whooper swans in Japan?

Conclusion

The H5N1 virus isolated from the whooper swans in Japan is genetically distinct from previous strains that caused outbreaks in the country.

Supporting Evidence

  • The H5N1 virus was isolated from four whooper swans found dead.
  • The virus was shown to be highly pathogenic to chickens.
  • Phylogenetic analysis indicated that the virus belongs to clade 2.3.2.
  • The virus was genetically distinguishable from previous strains in Japan.
  • Previous outbreaks in Japan were caused by different clades of H5N1.

Takeaway

Some swans in Japan got sick from a dangerous bird flu virus called H5N1, and scientists found that this virus is different from the ones that caused problems before.

Methodology

The study involved isolating the H5N1 virus from the tracheas, cloacas, and internal organs of dead whooper swans and analyzing it through various tests.

Participant Demographics

The study focused on whooper swans found in Akita Prefecture, Japan.

Digital Object Identifier (DOI)

10.3201/eid1409.080655

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