Anticoagulant treatment does not affect the action of flavone acetic acid in tumour-bearing mice
1991
Effects of Anticoagulants on Flavone Acetic Acid in Tumor-Bearing Mice
Sample size: 20
publication
Evidence: moderate
Author Information
Author(s): G. Thurston, K.A. Smith, J.C. Murray
Primary Institution: CRC Gray Laboratory, Mount Vernon Hospital
Hypothesis
Does anticoagulant treatment affect the antitumor action of flavone acetic acid in tumor-bearing mice?
Conclusion
Anticoagulant treatment does not significantly alter the antitumor effects of flavone acetic acid in mice.
Supporting Evidence
- Flavone acetic acid was shown to induce a coagulopathy in tumor-bearing mice.
- Anticoagulants heparin and ancrod were most effective at altering coagulation parameters.
- Neither heparin nor ancrod significantly reduced the tumor growth delay induced by FAA.
Takeaway
This study looked at whether blood thinners change how well a cancer drug works in mice, and it found that they don't.
Methodology
The study tested various anticoagulants on tumor-bearing mice to assess their effects on coagulation and tumor growth.
Limitations
The study was conducted only in mice, and results may not directly translate to humans.
Participant Demographics
12-16 week old male CBA/HtBSVS mice
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