Afterload-related cardiac performance in sepsis patients
Author Information
Author(s): Wilhelm J, Hettwer S, Schürmann M, Bagger S, Gerhardt F, Mundt S, Muschick S, Zimmermann J, Ebelt H, Werdan K
Primary Institution: Martin-Luther-University, Halle (Saale), Germany
Hypothesis
The study investigates the prognostic relevance of afterload-related cardiac performance (ACP) compared to cardiac index (CI) and cardiac power index (CPI) in patients with community-acquired sepsis.
Conclusion
The study found that ACP is a better indicator of early cardiac function impairment in sepsis patients than CI or CPI.
Supporting Evidence
- 48.2% of patients had sepsis, 33.6% had severe sepsis, and 18.2% had septic shock.
- Overall 30-day mortality was 10.9%.
- ACP was significantly lower in severe sepsis and septic shock compared to patients with sepsis without organ dysfunction.
- Nonsurvivors had a significantly depressed ACP on admission and after 72 hours.
- Only ACP correlated with serum levels of procalcitonin and IL-6.
Takeaway
Doctors can use a measure called ACP to see how well the heart is working in sick patients, which helps them know who might get worse.
Methodology
Patients with community-acquired sepsis were assessed for cardiac function using non-invasive and invasive methods to measure CI, CPI, and ACP.
Participant Demographics
Patients aged 18 and older with community-acquired sepsis.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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