ACE Inhibitors and Comorbidities in Diabetes
Author Information
Author(s): Maria E Ramos-Nino, Charles D MacLean, Benjamin Littenberg
Primary Institution: University of Vermont
Hypothesis
Is there an association between ACE inhibitor therapy and the prevalence of comorbid conditions in adults with diabetes?
Conclusion
ACE inhibitor use is associated with a lower likelihood of a history of cancer and peptic ulcers in patients with diabetes.
Supporting Evidence
- ACE users reported a history of cancer less frequently than non-users (10% vs. 15%).
- ACE inhibitors were significantly inversely associated with a personal history of cancer.
- ACE inhibitors were also inversely associated with peptic ulcer disease.
Takeaway
People with diabetes who take ACE inhibitors are less likely to have had cancer or stomach ulcers.
Methodology
The study surveyed 1003 adults with diabetes, collecting data on comorbidities and medication use through home interviews and direct observation.
Potential Biases
Potential biases may arise from self-reporting of comorbid conditions and the cross-sectional nature of the study.
Limitations
The study is limited by its cross-sectional design, reliance on self-reported diagnoses, and lack of information on the timing and duration of ACE inhibitor use.
Participant Demographics
The study included adults with diabetes from community practices in Northern New England, with a mean age of 64.8 years.
Statistical Information
P-Value
0.01
Confidence Interval
[0.39, 0.89]
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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