Genetics of Saline and Cocaine Use in Mice
Author Information
Author(s): Khan Arshad H., Bagley Jared R., LaPierre Nathan, Gonzalez-Figueroa Carlos, Spencer Tadeo C., Choudhury Mudra, Xiao Xinshu, Eskin Eleazar, Jentsch James D., Smith Desmond J.
Primary Institution: Cold Spring Harbor Laboratory
Hypothesis
What are the genetic factors influencing the response to saline and cocaine in mice?
Conclusion
The study found distinct genetic bases for saline and cocaine self-administration in mice.
Supporting Evidence
- 145 loci were identified for saline self-administration compared to 17 for cocaine.
- Only one locus overlapped between saline and cocaine responses.
- 5031434O11Rik and Zfp60 were significant for saline self-administration.
- Myh4 and Npc1 were nominated based on their proximity to significant loci.
Takeaway
Scientists studied mice to see how their genes affect their behavior when given saline or cocaine, and found that different genes are involved for each.
Methodology
Genome-wide association studies (GWASs) and transcriptome-wide association studies (TWASs) were performed on inbred and recombinant inbred mice over 10 days.
Participant Demographics
Inbred and recombinant inbred mice were used in the study.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website