EGFR Gene Amplification in Cervical Cancer
Author Information
Author(s): Iida K, Nakayama K, Rahman M T, Rahman M, Ishikawa M, Katagiri A, Yeasmin S, Otsuki Y, Kobayashi H, Nakayama S, Miyazaki K
Primary Institution: Shimane University School of Medicine
Hypothesis
The study investigates the relationship between EGFR gene amplification and clinical outcomes in cervical squamous cell carcinoma.
Conclusion
EGFR gene amplification is associated with shorter overall survival in cervical squamous cell carcinoma patients.
Supporting Evidence
- 10.2% of cervical squamous cell carcinomas showed significant amplification of the EGFR locus.
- EGFR amplification significantly correlated with shorter overall survival.
- EGFR gene amplification was an independent prognostic factor for overall survival.
Takeaway
This study found that some cervical cancer cells have extra copies of a gene called EGFR, which can make the cancer worse.
Methodology
The study used immunohistochemistry, fluorescence in situ hybridization, and PCR to assess EGFR expression, amplification, and mutations in cervical carcinomas.
Potential Biases
Differences in methodological protocols may introduce variability in results.
Limitations
The study's sample size is relatively small, which may affect the reliability of the results.
Participant Demographics
Median patient age was 60 years for squamous cell carcinoma and 46 years for adenocarcinoma/adenosquamous carcinoma.
Statistical Information
P-Value
0.001
Confidence Interval
95% CI not provided
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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