Arginase and Arginine Dysregulation in Asthma
2011
Arginase and Arginine Dysregulation in Asthma
publication
Evidence: moderate
Author Information
Author(s): Renée C. Benson, Karen A. Hardy, Claudia R. Morris
Primary Institution: Children's Hospital & Research Center Oakland
Hypothesis
Arginase plays a key role in the pathogenesis of asthma through dysregulation of L-arginine metabolism.
Conclusion
Increased arginase activity contributes to airway hyperresponsiveness and inflammation in asthma.
Supporting Evidence
- Arginase decreases the availability of L-arginine for nitric oxide synthase, limiting nitric oxide production.
- Increased arginase activity is associated with airway hyperresponsiveness in asthma.
- Arginase may contribute to airway remodeling through the production of L-ornithine and polyamines.
Takeaway
Arginase is an enzyme that can make asthma worse by reducing a substance called L-arginine, which is important for keeping airways open.
Limitations
The study primarily discusses mechanisms and does not provide direct clinical trial data.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website