Antifungal Activity of Sapindus saponaria Extracts Against Vaginal Candida
Author Information
Author(s): Damke Edílson, Tsuzuki Joyce K, Cortez Diógenes AG, Ferreira Izabel CP, Bertoni Thâmara A, Batista Márcia R, Donati Lucélia, Svidzinski Terezinha IE, Consolaro Márcia EL
Primary Institution: State University of Maringá, Paraná, Brazil
Hypothesis
The hydroalcoholic and butanolic extracts of Sapindus saponaria have antifungal activity against azole-susceptible and -resistant human vaginal Candida species.
Conclusion
The extracts from Sapindus saponaria effectively eliminated vaginal infections caused by both azole-resistant and -susceptible Candida species in a rat model.
Supporting Evidence
- The extracts showed in vitro inhibitory and fungicidal activity against all the isolates.
- In vivo, the infections were eliminated by 21 days post-infection.
- No cytotoxic action was observed for either extract.
Takeaway
This study shows that a plant called Sapindus saponaria can help fight infections caused by certain yeasts that make people sick.
Methodology
The study involved in vitro and in vivo tests using hydroalcoholic and butanolic extracts of Sapindus saponaria on vaginal Candida species in rats.
Limitations
The study did not use purified antifungal substances for comparison.
Participant Demographics
Wistar rats weighing 200-300 g were used in the study.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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