Prevalence of Invasive Fungal Disease in Hematological Patients
Author Information
Author(s): Lee Siok-Ying, Yeo Chay-Leng, Lee Winnie H, Kwa Andrea L, Koh Liang-Piu, Hsu Li-Yang
Primary Institution: Khoo Teck Puat Hospital, National University Hospital, Singapore General Hospital
Hypothesis
The study aims to determine the prevalence and types of invasive fungal disease (IFD) in hematological patients at a tertiary university hospital.
Conclusion
The burden of IFD is high in the institution, particularly among allogeneic HSCT recipients and patients undergoing induction chemotherapy for AML.
Supporting Evidence
- 39 cases of IFD were diagnosed during the study period.
- Aspergillus spp. accounted for 83.9% of all probable and definite infections.
- The in-hospital mortality rate was 28.2%, with 12.8% of deaths attributed to IFD.
- IFD occurred in 9.7% of AML patients and 3.9% of ALL patients treated at the institution.
- Fluconazole prophylaxis was provided for 71.8% of cases.
Takeaway
This study found that many patients with blood cancers get serious fungal infections, and using certain medicines might help prevent them.
Methodology
A retrospective chart review of hematological patients diagnosed with IFD from October 2007 to April 2010.
Limitations
The study is retrospective, and not all cases of IFD may have been diagnosed; no autopsies were performed on deceased patients.
Participant Demographics
{"median_age":43,"gender_distribution":{"male":64.1,"female":35.9},"diagnosis":{"AML":{"total":124,"with_IFD":12,"percentage":9.7},"ALL":{"total":103,"with_IFD":4,"percentage":3.9},"HSCT":{"total":62,"with_IFD":10,"percentage":16.1}}}
Digital Object Identifier (DOI)
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