Case of Leiomyosarcoma in a Breast Cancer Patient
Author Information
Author(s): Jennifer De la Pena, Irene Wapnir
Primary Institution: Stanford University
Hypothesis
Could cyclophosphamide exposure contribute to the development of breast leiomyosarcoma?
Conclusion
The patient developed a low-grade leiomyosarcoma after a long history of cyclophosphamide exposure, but remains disease-free after treatment.
Supporting Evidence
- Breast sarcomas are rare and comprise only 1% of malignancies.
- Leiomyosarcomas usually present as enlarging palpable masses.
- Patients with collagen vascular diseases have increased late toxicity with radiotherapy.
Takeaway
A woman who took a medicine for a long time found a lump in her breast, and doctors discovered it was a rare type of cancer, but she is doing well after surgery.
Methodology
The patient underwent ultrasound guided core biopsy and mastectomy with sentinel lymph node biopsy.
Limitations
The rarity of breast sarcomas limits generalizability of findings.
Participant Demographics
A 50-year-old woman with a history of systemic lupus erythematosus and intermittent cyclophosphamide therapy.
Digital Object Identifier (DOI)
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