Immune-Inflammatory Index and Coronary Collateralization in Diabetic Patients
Author Information
Author(s): Mao Lin Shuang, Wang Yi Xuan, Wu Zhi Ming, Ding Feng Hua, Lu Lin, Shen Wei Feng, Dai Yang, Shen Ying
Primary Institution: Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine
Hypothesis
This study aimed to compare the value of different systemic immune-inflammatory markers for evaluating coronary collateralization in patients with type 2 diabetes mellitus and chronic total occlusion.
Conclusion
Elevated systemic immune-inflammatory index predicts poor coronary collateralization in type 2 diabetic patients with chronic total occlusion.
Supporting Evidence
- SII, SIRI, and PIV levels increased stepwise across Rentrop score 0–3.
- Patients with poor CC had significantly higher levels of SII, SIRI, and PIV compared to those with good CC.
- SII predicted poor CC better than SIRI and PIV.
- High SII levels were associated with a greater risk of poor CC in patients with HbA1c < 6.5%.
Takeaway
Doctors found that a specific blood test can help predict how well blood vessels are growing in people with diabetes who have blocked arteries.
Methodology
The study calculated systemic immune-inflammation index, systemic inflammation response index, and pan-immune-inflammation value in 1409 patients and assessed coronary collateralization using the Rentrop scoring system.
Potential Biases
Potential selection bias due to the single-center design and exclusion of certain patient groups.
Limitations
The study was a single-center retrospective analysis, which may not represent the broader population, and some confounding factors were not included.
Participant Demographics
Participants were type 2 diabetes patients aged 18 and older with chronic total occlusion.
Statistical Information
P-Value
p<0.001
Confidence Interval
95% CI, 0.735–0.781
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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