HHV-8 Seroprevalence in Native Americans
Author Information
Author(s): Souza Vanda A.U.F., Salzano Francisco M., Petzl-Erler Maria Luiza, Nascimento Maria Claudia, Mayaud Philippe, Borges Jaila Dias, Pannuti Claudio S.
Primary Institution: Universidade de São Paulo, São Paulo, Brazil
Hypothesis
To determine the epidemiology of human herpesvirus type 8 (HHV-8) among non-Amazonian native populations.
Conclusion
The study found significant geographic and ethnic variations in HHV-8 seroprevalence among South American native populations.
Supporting Evidence
- HHV-8 seroprevalence is low in northern Europe and North America, but high in Amazonian Native Americans.
- Significant differences in HHV-8 seroprevalence were observed between Amazonian and non-Amazonian populations.
- Nearly one fourth of HHV-8–seropositive persons shed HHV-8 DNA in their saliva.
Takeaway
This study looked at how common a virus called HHV-8 is among Native Americans in South America, finding big differences based on where they live.
Methodology
A cross-sectional study was conducted with serum samples collected from various Native American populations and analyzed for HHV-8 antibodies using immunofluorescence assays.
Potential Biases
Selection bias cannot be excluded due to the recruitment of study participants.
Limitations
The study lacks the power to assess statistically significant differences in HHV-8 seroprevalences by geographic region and may have selection bias.
Participant Demographics
Participants ranged from 1 to 70 years of age, with informed consent obtained from individuals and guardians.
Statistical Information
P-Value
0.7
Statistical Significance
p trend<0.001
Digital Object Identifier (DOI)
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