Comparing Atenolol and Clonidine for Heart Rate Control During Surgery
Author Information
Author(s): Devendra Gupta, Shashi Srivastava, Rajeev K Dubey, Prakash Prabhakar, Prabhat K Singh, Uttam Singh
Primary Institution: Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
Hypothesis
Does preoperative administration of clonidine or atenolol reduce cardiovascular responses during nasal speculum insertion in pituitary surgery?
Conclusion
Both oral clonidine and atenolol effectively reduce heart rate and blood pressure responses during nasal speculum insertion in pituitary surgery.
Supporting Evidence
- Heart rate increased in the control group during speculum insertion, while it remained stable in the clonidine and atenolol groups.
- Mean arterial pressure rose in the control group but not in the other groups during and after speculum insertion.
- Both atenolol and clonidine were administered 2 hours prior to surgery to match peak plasma concentration with the procedure.
Takeaway
Doctors gave patients two different medicines before surgery to see which one helped keep their heart rate and blood pressure steady when a tool was used in their nose.
Methodology
This was a prospective, randomised, double-blind, placebo-controlled study involving 66 patients undergoing elective surgery, divided into three groups receiving placebo, clonidine, or atenolol.
Potential Biases
Potential bias in patient selection and the effects of different surgical techniques.
Limitations
The study excluded patients with certain medical conditions, which may limit the generalizability of the results.
Participant Demographics
Patients aged 18-65 years, ASA I–II, of either sex.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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