High prevalence of myositis in pediatric lupus patients
Author Information
Author(s): Jessica L Record, Timothy Beukelman, Randy Q Cron
Primary Institution: University of Alabama at Birmingham
Hypothesis
What is the prevalence of myositis in pediatric systemic lupus erythematosus patients in the southeastern United States?
Conclusion
Pediatric systemic lupus erythematosus patients in Alabama have a significantly higher prevalence of myositis compared to previously reported rates in adults.
Supporting Evidence
- 31% of pediatric SLE patients in the study had myositis.
- Myositis was positively associated with anti-RNP antibodies.
- The prevalence of myositis in this cohort is significantly higher than the 4-16% reported in adults.
Takeaway
This study found that many kids with lupus also have muscle problems, which is more common than what we thought before.
Methodology
A retrospective chart review of 55 pediatric SLE patients was conducted to determine the prevalence of myositis.
Potential Biases
Potential bias due to the retrospective nature of the study and reliance on medical records.
Limitations
The study relied on clinical and laboratory definitions of myositis rather than invasive testing.
Participant Demographics
The cohort consisted of 87.3% female and 74.5% African-American patients, with a mean age of 16 years.
Statistical Information
P-Value
p < 0.0001
Confidence Interval
95% CI 19-45%
Statistical Significance
p < 0.0001
Digital Object Identifier (DOI)
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